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        • Amplification biochips and implantable bar-code sensors | Thrust 1
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Thrust 1

You are here: Home / Research / Thrust 1

Amplification Biochips and Implantable Bar-code Sensors

Thrust Leads 

UCLA 
Thrust Co-Lead

Dino DiCarlo

UCLA  Thrust Co-Lead
TAMU 
Thrust Co-Lead

Mike McShane

TAMU  Thrust Co-Lead

Goals: Thrust 1 will develop amplification biochips and implantable bar-code sensors for point-of-care (POC) monitoring of cardiovascular disease and diabetes biomarkers. There are two main projects for Thrust 1.

Project 1.1: Design and validation of cartridge-based assays and systems using microfluidics, paper fluidics, nanoparticles, and amplification 

Project 1.1 is designed to be integrated with T2.1, namely the design and validation of mobile and cost-effective reader platforms to overcome key challenges and gaps in existing technologies toward developing the Lab in your Palm-engineered systems for cardiovascular and diabetes applications.

This project includes three tasks focused on the parallel development of (1) nanostructure-based biosensors, (2) cost-effective material-based biosensors, and (3) emerging biomarkers technologies.

UCLA 
Thrust Co-Lead

Dino DiCarlo

UCLA  Thrust Co-Lead
TAMU

Gerard L. Coté

TAMU
FIU

Jessica Ramella-Roman

FIU
UCLA

Aydogan Ozcan

UCLA
TAMU

Samuel Mabbott

TAMU
FIU

Josh Hutcheson

FIU
UCLA

Omai Garner

UCLA
TAMU

Carl Tong

TAMU
Paper-based multi target diagnostic test enables new applications

Thrust 1.1 Research Highlights

Lab on a Chip cover 2021

Lab on a Chip (2021)- Front Cover

Counting of enzymatically amplified affinity reactions in hydrogel particle-templated drops – Lab on a Chip (RSC Publishing)

Yilian Wang, Vishwesh Shah, Angela Lu, Ella Pachler, Brian Cheng, Dino Di Carlo

Cover of ACS Sensors September 2021

ACS Sensors (2020) – Front Cover

Fabrication of 3D concentric amphiphilic microparticles to form uniform nanoliter reaction volumes for amplified affinity assays 

Ghulam Destgeer, Mengxing Ouyang, Chueh-Yu Wua and Dino Di Carlo

Methylation-Sensitive Loop-Mediated Isothermal Amplification (LAMP): Nucleic Acid Methylation Detection through LAMP with Mobile Fluorescence Readout

ACS Sensors (2021) – Editors Choice

Methylation-Sensitive Loop-Mediated Isothermal Amplification (LAMP): Nucleic Acid Methylation Detection through LAMP with Mobile Fluorescence Readout 

Jacob Amos Hambalek, Janay Elise Kong, Calvin Brown, Hector Enrique Munoz, Thomas Horn, Michael Bogumil, Eleni Quick, Aydogan Ozcan, and Dino Di Carlo

Project 1.2: Design and validation of implantable systems including optimization of the transduction and recognition elements of the assay and development of biocompatible materials

T1.2 is designed to be integrated with T2 project 2 and T3 projects 1 and 3, to overcome the key challenges of the Lab on your Wrist implantable engineered system primarily for diabetes applications.

This project includes two main tasks focused on the parallel development of (1) biocompatible materials for encapsulating/packaging bio-sensing assays, and (2) multiplexed (“barcoded”) assays for monitoring multiple analytes with a single inserted device.

TAMU 
Thrust Co-Lead

Mike McShane

TAMU  Thrust Co-Lead
UCLA 
Thrust Co-Lead

Dino DiCarlo

UCLA  Thrust Co-Lead
TAMU

Melissa Grunlan

TAMU
TAMU

Gerard L. Coté

TAMU
Research photo of Insertable Phosphorescent barcodes and Insertable Fluorescence assay in hollow rods

Thrust 1.2 Research Highlights

A Glucose Biosensor Based on Phosphorescence Lifetime Sensing and a Thermoresponsive Membrane

Macromolecular Rapid Communications (2022)

A Glucose Biosensor Based on Phosphorescence Lifetime Sensing and a Thermoresponsive Membrane

Ping Dong, Brian S. Ko, Kayllie A. Lomeli, Emily C. Clark, Michael J. McShane, Melissa A. Grunlan

Multidomain-Based Responsive Materials with Dual-Mode Optical Readouts

ACS Applied Materials & Interfaces (2019)

Multidomain-Based Responsive Materials with Dual-Mode Optical Readouts

Yil-Hwan You, Aniket Biswas, Ashvin T. Nagaraja, Jin-Ha Hwang, Gerard L. Coté, and Michael J. McShane

Illustration of the FRET responses that occurred as 10 μΜ AF-700-PEG was introduced to increasing concentrations of AF-750-ConA and held within microcentrifuge tubes that were then placed beneath rat skin samples of (a) lighter and (b) darker pigmentations. The pigmentations are displayed within each graph.

SPIE BiOS (2019)

Assessment of wavelengths with skin tones for an implantable FRET-based glucose biosensor

Lydia E. Colvin, Ping Dong, A. Kristen Means, Melissa A. Grunlan, Gerard L. Coté

Thrust 1 Publications

PATHS-UP Members

Texas A&M University
UCLA
Rice University
Florida International University

Evaluation Partner

Arizona State University

Funded By
NSF

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